An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.
Identifieur interne : 001719 ( Main/Exploration ); précédent : 001718; suivant : 001720An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.
Auteurs : Sophie Caillard [France] ; Dany Anglicheau [France] ; Marie Matignon [France] ; Antoine Durrbach [France] ; Clarisse Greze [France] ; Luc Frimat [France] ; Olivier Thaunat [France] ; Tristan Legris [France] ; Valerie Moal [France] ; Pierre Francois Westeel [France] ; Nassim Kamar [France] ; Philippe Gatault [France] ; Renaud Snanoudj [France] ; Antoine Sicard [France] ; Dominique Bertrand [France] ; Charlotte Colosio [France] ; Lionel Couzi [France] ; Jonathan M. Chemouny [France] ; Christophe Masset [France] ; Gilles Blancho [France] ; Jamal Bamoulid [France] ; Agnes Duveau [France] ; Nicolas Bouvier [France] ; Nathalie Chavarot [France] ; Philippe Grimbert [France] ; Bruno Moulin [France] ; Yannick Le Meur [France] ; Marc Hazzan [France]Source :
- Kidney international [ 1523-1755 ] ; 2020.
Abstract
Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.
DOI: 10.1016/j.kint.2020.08.005
PubMed: 32853631
PubMed Central: PMC7444636
Affiliations:
- France
- Alsace (région administrative), Aquitaine, Auvergne-Rhône-Alpes, Basse-Normandie, Bourgogne-Franche-Comté, Centre-Val de Loire, Champagne-Ardenne, Franche-Comté, Grand Est, Haute-Normandie, Hauts-de-France, Lorraine (région), Midi-Pyrénées, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Occitanie (région administrative), Pays de la Loire, Picardie, Provence-Alpes-Côte d'Azur, Rhône-Alpes, Région Bretagne, Région Centre, Région Normandie, Île-de-France
- Amiens, Angers, Besançon, Bordeaux, Brest, Caen, Créteil, Lille, Lyon, Marseille, Nancy, Nantes, Nice, Paris, Reims, Rennes, Rouen, Strasbourg, Toulouse, Tours
- Université Claude Bernard Lyon 1, Université d'Aix-Marseille, Université de Bordeaux
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Electronic address: Sophie.caillard@chru-strasbourg.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Anglicheau, Dany" sort="Anglicheau, Dany" uniqKey="Anglicheau D" first="Dany" last="Anglicheau">Dany Anglicheau</name><affiliation wicri:level="3"><nlm:affiliation>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Matignon, Marie" sort="Matignon, Marie" uniqKey="Matignon M" first="Marie" last="Matignon">Marie Matignon</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Durrbach, Antoine" sort="Durrbach, Antoine" uniqKey="Durrbach A" first="Antoine" last="Durrbach">Antoine Durrbach</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Greze, Clarisse" sort="Greze, Clarisse" uniqKey="Greze C" first="Clarisse" last="Greze">Clarisse Greze</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Hôpital Bichat, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Frimat, Luc" sort="Frimat, Luc" uniqKey="Frimat L" first="Luc" last="Frimat">Luc Frimat</name><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, CHRU-Nancy, Department of Nephrology, Vandoeuvre, France INSERM CIC-EC CIE6, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, CHRU-Nancy, Department of Nephrology, Vandoeuvre, France INSERM CIC-EC CIE6, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Thaunat, Olivier" sort="Thaunat, Olivier" uniqKey="Thaunat O" first="Olivier" last="Thaunat">Olivier Thaunat</name><affiliation wicri:level="4"><nlm:affiliation>Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Edouard Herriot, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Edouard Herriot, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Legris, Tristan" sort="Legris, Tristan" uniqKey="Legris T" first="Tristan" last="Legris">Tristan Legris</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Moal, Valerie" sort="Moal, Valerie" uniqKey="Moal V" first="Valerie" last="Moal">Valerie Moal</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Westeel, Pierre Francois" sort="Westeel, Pierre Francois" uniqKey="Westeel P" first="Pierre Francois" last="Westeel">Pierre Francois Westeel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Amiens, Amiens, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Amiens, Amiens</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Picardie</region><settlement type="city">Amiens</settlement></placeName></affiliation></author><author><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Gatault, Philippe" sort="Gatault, Philippe" uniqKey="Gatault P" first="Philippe" last="Gatault">Philippe Gatault</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Snanoudj, Renaud" sort="Snanoudj, Renaud" uniqKey="Snanoudj R" first="Renaud" last="Snanoudj">Renaud Snanoudj</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology and Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Sicard, Antoine" sort="Sicard, Antoine" uniqKey="Sicard A" first="Antoine" last="Sicard">Antoine Sicard</name><affiliation wicri:level="3"><nlm:affiliation>Service de néphrologie-dialyse-transplantation, Hopital Pasteur 2, C.H.U. de Nice, Unité de Recherche Clinique Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de néphrologie-dialyse-transplantation, Hopital Pasteur 2, C.H.U. de Nice, Unité de Recherche Clinique Côte d'Azur (UR2CA), Université Côte d'Azur, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Bertrand, Dominique" sort="Bertrand, Dominique" uniqKey="Bertrand D" first="Dominique" last="Bertrand">Dominique Bertrand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Rouen, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Rouen, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Colosio, Charlotte" sort="Colosio, Charlotte" uniqKey="Colosio C" first="Charlotte" last="Colosio">Charlotte Colosio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Reims, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Reims, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Couzi, Lionel" sort="Couzi, Lionel" uniqKey="Couzi L" first="Lionel" last="Couzi">Lionel Couzi</name><affiliation wicri:level="4"><nlm:affiliation>Service de Néphrologie-Transplantation-Dialyse-Aphérèse, Hôpital Pellegrin, CHU de Bordeaux Pellegrin. Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Néphrologie-Transplantation-Dialyse-Aphérèse, Hôpital Pellegrin, CHU de Bordeaux Pellegrin. Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux</wicri:regionArea><wicri:noRegion>CHU de Bordeaux Pellegrin. Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux</wicri:noRegion><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Chemouny, Jonathan M" sort="Chemouny, Jonathan M" uniqKey="Chemouny J" first="Jonathan M" last="Chemouny">Jonathan M. Chemouny</name><affiliation wicri:level="3"><nlm:affiliation>Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, CIC-P 1414, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, CIC-P 1414, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Masset, Christophe" sort="Masset, Christophe" uniqKey="Masset C" first="Christophe" last="Masset">Christophe Masset</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Bamoulid, Jamal" sort="Bamoulid, Jamal" uniqKey="Bamoulid J" first="Jamal" last="Bamoulid">Jamal Bamoulid</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, University of Besançon, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, University of Besançon, Besançon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Duveau, Agnes" sort="Duveau, Agnes" uniqKey="Duveau A" first="Agnes" last="Duveau">Agnes Duveau</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Angers, Angers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Angers, Angers</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Bouvier, Nicolas" sort="Bouvier, Nicolas" uniqKey="Bouvier N" first="Nicolas" last="Bouvier">Nicolas Bouvier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Caen, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Caen, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Chavarot, Nathalie" sort="Chavarot, Nathalie" uniqKey="Chavarot N" first="Nathalie" last="Chavarot">Nathalie Chavarot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Grimbert, Philippe" sort="Grimbert, Philippe" uniqKey="Grimbert P" first="Philippe" last="Grimbert">Philippe Grimbert</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Moulin, Bruno" sort="Moulin, Bruno" uniqKey="Moulin B" first="Bruno" last="Moulin">Bruno Moulin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Le Meur, Yannick" sort="Le Meur, Yannick" uniqKey="Le Meur Y" first="Yannick" last="Le Meur">Yannick Le Meur</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Labex IGO, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Labex IGO, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Hazzan, Marc" sort="Hazzan, Marc" uniqKey="Hazzan M" first="Marc" last="Hazzan">Marc Hazzan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32853631</idno><idno type="pmid">32853631</idno><idno type="doi">10.1016/j.kint.2020.08.005</idno><idno type="pmc">PMC7444636</idno><idno type="wicri:Area/Main/Corpus">000335</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000335</idno><idno type="wicri:Area/Main/Curation">000335</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000335</idno><idno type="wicri:Area/Main/Exploration">000335</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.</title><author><name sortKey="Caillard, Sophie" sort="Caillard, Sophie" uniqKey="Caillard S" first="Sophie" last="Caillard">Sophie Caillard</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg, France. Electronic address: Sophie.caillard@chru-strasbourg.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Anglicheau, Dany" sort="Anglicheau, Dany" uniqKey="Anglicheau D" first="Dany" last="Anglicheau">Dany Anglicheau</name><affiliation wicri:level="3"><nlm:affiliation>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Matignon, Marie" sort="Matignon, Marie" uniqKey="Matignon M" first="Marie" last="Matignon">Marie Matignon</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Durrbach, Antoine" sort="Durrbach, Antoine" uniqKey="Durrbach A" first="Antoine" last="Durrbach">Antoine Durrbach</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Greze, Clarisse" sort="Greze, Clarisse" uniqKey="Greze C" first="Clarisse" last="Greze">Clarisse Greze</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Hôpital Bichat, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Frimat, Luc" sort="Frimat, Luc" uniqKey="Frimat L" first="Luc" last="Frimat">Luc Frimat</name><affiliation wicri:level="3"><nlm:affiliation>University of Lorraine, CHRU-Nancy, Department of Nephrology, Vandoeuvre, France INSERM CIC-EC CIE6, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lorraine, CHRU-Nancy, Department of Nephrology, Vandoeuvre, France INSERM CIC-EC CIE6, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Thaunat, Olivier" sort="Thaunat, Olivier" uniqKey="Thaunat O" first="Olivier" last="Thaunat">Olivier Thaunat</name><affiliation wicri:level="4"><nlm:affiliation>Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Edouard Herriot, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Edouard Herriot, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Legris, Tristan" sort="Legris, Tristan" uniqKey="Legris T" first="Tristan" last="Legris">Tristan Legris</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Moal, Valerie" sort="Moal, Valerie" uniqKey="Moal V" first="Valerie" last="Moal">Valerie Moal</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Westeel, Pierre Francois" sort="Westeel, Pierre Francois" uniqKey="Westeel P" first="Pierre Francois" last="Westeel">Pierre Francois Westeel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Amiens, Amiens, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Amiens, Amiens</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Picardie</region><settlement type="city">Amiens</settlement></placeName></affiliation></author><author><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Gatault, Philippe" sort="Gatault, Philippe" uniqKey="Gatault P" first="Philippe" last="Gatault">Philippe Gatault</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Tours, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Tours, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Snanoudj, Renaud" sort="Snanoudj, Renaud" uniqKey="Snanoudj R" first="Renaud" last="Snanoudj">Renaud Snanoudj</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology and Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Sicard, Antoine" sort="Sicard, Antoine" uniqKey="Sicard A" first="Antoine" last="Sicard">Antoine Sicard</name><affiliation wicri:level="3"><nlm:affiliation>Service de néphrologie-dialyse-transplantation, Hopital Pasteur 2, C.H.U. de Nice, Unité de Recherche Clinique Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de néphrologie-dialyse-transplantation, Hopital Pasteur 2, C.H.U. de Nice, Unité de Recherche Clinique Côte d'Azur (UR2CA), Université Côte d'Azur, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Bertrand, Dominique" sort="Bertrand, Dominique" uniqKey="Bertrand D" first="Dominique" last="Bertrand">Dominique Bertrand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Rouen, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Rouen, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Colosio, Charlotte" sort="Colosio, Charlotte" uniqKey="Colosio C" first="Charlotte" last="Colosio">Charlotte Colosio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Reims, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Reims, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Couzi, Lionel" sort="Couzi, Lionel" uniqKey="Couzi L" first="Lionel" last="Couzi">Lionel Couzi</name><affiliation wicri:level="4"><nlm:affiliation>Service de Néphrologie-Transplantation-Dialyse-Aphérèse, Hôpital Pellegrin, CHU de Bordeaux Pellegrin. Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Néphrologie-Transplantation-Dialyse-Aphérèse, Hôpital Pellegrin, CHU de Bordeaux Pellegrin. Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux</wicri:regionArea><wicri:noRegion>CHU de Bordeaux Pellegrin. Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux</wicri:noRegion><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Chemouny, Jonathan M" sort="Chemouny, Jonathan M" uniqKey="Chemouny J" first="Jonathan M" last="Chemouny">Jonathan M. Chemouny</name><affiliation wicri:level="3"><nlm:affiliation>Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, CIC-P 1414, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, CIC-P 1414, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Masset, Christophe" sort="Masset, Christophe" uniqKey="Masset C" first="Christophe" last="Masset">Christophe Masset</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Bamoulid, Jamal" sort="Bamoulid, Jamal" uniqKey="Bamoulid J" first="Jamal" last="Bamoulid">Jamal Bamoulid</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, University of Besançon, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, University of Besançon, Besançon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Duveau, Agnes" sort="Duveau, Agnes" uniqKey="Duveau A" first="Agnes" last="Duveau">Agnes Duveau</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Angers, Angers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Angers, Angers</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Bouvier, Nicolas" sort="Bouvier, Nicolas" uniqKey="Bouvier N" first="Nicolas" last="Bouvier">Nicolas Bouvier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Caen, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Caen, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Chavarot, Nathalie" sort="Chavarot, Nathalie" uniqKey="Chavarot N" first="Nathalie" last="Chavarot">Nathalie Chavarot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Grimbert, Philippe" sort="Grimbert, Philippe" uniqKey="Grimbert P" first="Philippe" last="Grimbert">Philippe Grimbert</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Moulin, Bruno" sort="Moulin, Bruno" uniqKey="Moulin B" first="Bruno" last="Moulin">Bruno Moulin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Le Meur, Yannick" sort="Le Meur, Yannick" uniqKey="Le Meur Y" first="Yannick" last="Le Meur">Yannick Le Meur</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Labex IGO, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Labex IGO, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Hazzan, Marc" sort="Hazzan, Marc" uniqKey="Hazzan M" first="Marc" last="Hazzan">Marc Hazzan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology and Transplantation, University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology and Transplantation, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">Kidney international</title><idno type="eISSN">1523-1755</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32853631</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-1755</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>24</Day></PubDate></JournalIssue><Title>Kidney international</Title><ISOAbbreviation>Kidney Int.</ISOAbbreviation></Journal><ArticleTitle>An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0085-2538(20)30961-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.kint.2020.08.005</ELocationID><Abstract><AbstractText>Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. Risk factors for severe disease or death were determined. Of the 279 patients, 243 were admitted to hospital and 36 were managed at home. The median age of hospitalized patients was 61.6 years; most had comorbidities (hypertension, 90.1%; overweight, 63.8%; diabetes, 41.3%; cardiovascular disease, 36.2%). Fever, cough, dyspnea, and diarrhea were the most common symptoms on admission. Laboratory findings revealed mild inflammation frequently accompanied by lymphopenia. Immunosuppressive drugs were generally withdrawn (calcineurin inhibitors: 28.7%; antimetabolites: 70.8%). Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). Severe Covid-19 occurred in 106 patients (46%). Forty-three hospitalized patients died (30-day mortality 22.8%). Multivariable analysis identified overweight, fever, and dyspnea as independent risk factors for severe disease, whereas age over 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. Thus, Covid-19 in recipients of kidney transplants portends a high mortality rate. Proper management of immunosuppression and tailored treatment of this population remain challenging.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caillard</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg, France. Electronic address: Sophie.caillard@chru-strasbourg.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anglicheau</LastName><ForeName>Dany</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matignon</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durrbach</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greze</LastName><ForeName>Clarisse</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Hôpital Bichat, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frimat</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University of Lorraine, CHRU-Nancy, Department of Nephrology, Vandoeuvre, France INSERM CIC-EC CIE6, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thaunat</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Edouard Herriot, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Legris</LastName><ForeName>Tristan</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moal</LastName><ForeName>Valerie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Aix Marseille Université, Hôpitaux Universitaires de Marseille, Hôpital Conception, Centre de Néphrologie et Transplantation Rénale, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westeel</LastName><ForeName>Pierre Francois</ForeName><Initials>PF</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Amiens, Amiens, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamar</LastName><ForeName>Nassim</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gatault</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snanoudj</LastName><ForeName>Renaud</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sicard</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de néphrologie-dialyse-transplantation, Hopital Pasteur 2, C.H.U. de Nice, Unité de Recherche Clinique Côte d'Azur (UR2CA), Université Côte d'Azur, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertrand</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Rouen, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colosio</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Reims, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couzi</LastName><ForeName>Lionel</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service de Néphrologie-Transplantation-Dialyse-Aphérèse, Hôpital Pellegrin, CHU de Bordeaux Pellegrin. Unité Mixte de Recherche "ImmunoConcEpT" 5164 - Université de Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chemouny</LastName><ForeName>Jonathan M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, CIC-P 1414, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masset</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blancho</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bamoulid</LastName><ForeName>Jamal</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Nephrology, University of Besançon, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duveau</LastName><ForeName>Agnes</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouvier</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Caen, Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chavarot</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Service de Néphrologie et Transplantation Adultes, Hôpital Universitaire Necker - APHP Centre - Université de Paris INEM INSERM U 1151- CNRS UMR 8253, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimbert</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>AP-HP (Assistance Publique-Hôpitaux de Paris), Nephrology and Renal Transplantation Department, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Groupe Hospitalier Henri-Mondor/Albert-Chenevier. Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunité-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moulin</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, Strasbourg University Hospital, INSERM, IRM UMR-S 1109, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Meur</LastName><ForeName>Yannick</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Nephrology, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, Labex IGO, Brest, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hazzan</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Nephrology and Transplantation, University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>French SOT COVID Registry</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Kidney Int</MedlineTA><NlmUniqueID>0323470</NlmUniqueID><ISSNLinking>0085-2538</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Covid-19</Keyword><Keyword MajorTopicYN="N">immunosuppression</Keyword><Keyword MajorTopicYN="N">kidney transplantation</Keyword><Keyword MajorTopicYN="N">mortality</Keyword><Keyword MajorTopicYN="N">prognosis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>08</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32853631</ArticleId><ArticleId IdType="pii">S0085-2538(20)30961-3</ArticleId><ArticleId IdType="doi">10.1016/j.kint.2020.08.005</ArticleId><ArticleId 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Normandie</li><li>Île-de-France</li></region><settlement><li>Amiens</li><li>Angers</li><li>Besançon</li><li>Bordeaux</li><li>Brest</li><li>Caen</li><li>Créteil</li><li>Lille</li><li>Lyon</li><li>Marseille</li><li>Nancy</li><li>Nantes</li><li>Nice</li><li>Paris</li><li>Reims</li><li>Rennes</li><li>Rouen</li><li>Strasbourg</li><li>Toulouse</li><li>Tours</li></settlement><orgName><li>Université Claude Bernard Lyon 1</li><li>Université d'Aix-Marseille</li><li>Université de Bordeaux</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Caillard, Sophie" sort="Caillard, Sophie" uniqKey="Caillard S" first="Sophie" last="Caillard">Sophie Caillard</name></region><name sortKey="Anglicheau, Dany" sort="Anglicheau, Dany" uniqKey="Anglicheau D" first="Dany" last="Anglicheau">Dany Anglicheau</name><name sortKey="Bamoulid, Jamal" sort="Bamoulid, Jamal" uniqKey="Bamoulid J" first="Jamal" last="Bamoulid">Jamal Bamoulid</name><name sortKey="Bertrand, Dominique" sort="Bertrand, Dominique" uniqKey="Bertrand D" first="Dominique" last="Bertrand">Dominique Bertrand</name><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><name sortKey="Bouvier, Nicolas" sort="Bouvier, Nicolas" uniqKey="Bouvier N" first="Nicolas" last="Bouvier">Nicolas Bouvier</name><name sortKey="Chavarot, Nathalie" sort="Chavarot, Nathalie" uniqKey="Chavarot N" first="Nathalie" last="Chavarot">Nathalie Chavarot</name><name sortKey="Chemouny, Jonathan M" sort="Chemouny, Jonathan M" uniqKey="Chemouny J" first="Jonathan M" last="Chemouny">Jonathan M. Chemouny</name><name sortKey="Colosio, Charlotte" sort="Colosio, Charlotte" uniqKey="Colosio C" first="Charlotte" last="Colosio">Charlotte Colosio</name><name sortKey="Couzi, Lionel" sort="Couzi, Lionel" uniqKey="Couzi L" first="Lionel" last="Couzi">Lionel Couzi</name><name sortKey="Durrbach, Antoine" sort="Durrbach, Antoine" uniqKey="Durrbach A" first="Antoine" last="Durrbach">Antoine Durrbach</name><name sortKey="Duveau, Agnes" sort="Duveau, Agnes" uniqKey="Duveau A" first="Agnes" last="Duveau">Agnes Duveau</name><name sortKey="Frimat, Luc" sort="Frimat, Luc" uniqKey="Frimat L" first="Luc" last="Frimat">Luc Frimat</name><name sortKey="Gatault, Philippe" sort="Gatault, Philippe" uniqKey="Gatault P" first="Philippe" last="Gatault">Philippe Gatault</name><name sortKey="Greze, Clarisse" sort="Greze, Clarisse" uniqKey="Greze C" first="Clarisse" last="Greze">Clarisse Greze</name><name sortKey="Grimbert, Philippe" sort="Grimbert, Philippe" uniqKey="Grimbert P" first="Philippe" last="Grimbert">Philippe Grimbert</name><name sortKey="Hazzan, Marc" sort="Hazzan, Marc" uniqKey="Hazzan M" first="Marc" last="Hazzan">Marc Hazzan</name><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name><name sortKey="Le Meur, Yannick" sort="Le Meur, Yannick" uniqKey="Le Meur Y" first="Yannick" last="Le Meur">Yannick Le Meur</name><name sortKey="Legris, Tristan" sort="Legris, Tristan" uniqKey="Legris T" first="Tristan" last="Legris">Tristan Legris</name><name sortKey="Masset, Christophe" sort="Masset, Christophe" uniqKey="Masset C" first="Christophe" last="Masset">Christophe Masset</name><name sortKey="Matignon, Marie" sort="Matignon, Marie" uniqKey="Matignon M" first="Marie" last="Matignon">Marie Matignon</name><name sortKey="Moal, Valerie" sort="Moal, Valerie" uniqKey="Moal V" first="Valerie" last="Moal">Valerie Moal</name><name sortKey="Moulin, Bruno" sort="Moulin, Bruno" uniqKey="Moulin B" first="Bruno" last="Moulin">Bruno Moulin</name><name sortKey="Sicard, Antoine" sort="Sicard, Antoine" uniqKey="Sicard A" first="Antoine" last="Sicard">Antoine Sicard</name><name sortKey="Snanoudj, Renaud" sort="Snanoudj, Renaud" uniqKey="Snanoudj R" first="Renaud" last="Snanoudj">Renaud Snanoudj</name><name sortKey="Thaunat, Olivier" sort="Thaunat, Olivier" uniqKey="Thaunat O" first="Olivier" last="Thaunat">Olivier Thaunat</name><name sortKey="Westeel, Pierre Francois" sort="Westeel, Pierre Francois" uniqKey="Westeel P" first="Pierre Francois" last="Westeel">Pierre Francois Westeel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
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|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
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|clé= pubmed:32853631
|texte= An initial report from the French SOT COVID Registry suggests high mortality due to Covid-19 in recipients of kidney transplants.
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
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